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Chronic Urticaria in Special Populations: Pediatric, Pregnancy, and the Elderly

Matthew Robson1, Joshua S Bernstein1, Jonathan A Bernstein1

  • 1Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML#563, Cincinnati, OH 45267, USA.

Immunology and Allergy Clinics of North America
|June 27, 2024
PubMed

Insights

Chronic spontaneous urticaria (CSU) treatment guidelines are lacking for vulnerable groups. This review updates CSU management in children, pregnant women, and the elderly, addressing prevalence, diagnosis, and treatment options.

Area of Science:

  • Dermatology
  • Immunology
  • Pharmacology

Background:

  • Chronic urticaria is an inflammatory skin condition causing hives and swelling.
  • Current treatment guidelines for chronic spontaneous urticaria (CSU) have gaps concerning specific populations.
  • Vulnerable groups like children, pregnant women, and the elderly require tailored CSU management strategies.

Purpose of the Study:

  • To provide an updated review of chronic spontaneous urticaria (CSU) management.
  • To focus on special populations: children (0-18 years), pregnant women, and the elderly (>65 years).
  • To define prevalence, diagnostic considerations, and explore current/future management options for CSU in these groups.

Main Methods:

  • Literature review of existing studies and treatment guidelines.
  • Analysis of prevalence data for CSU in pediatric, pregnant, and geriatric cohorts.
  • Exploration of diagnostic challenges and therapeutic strategies specific to each population.

Main Results:

  • Prevalence and diagnostic nuances of CSU vary across pediatric, pregnant, and elderly populations.
  • Current evidence suggests specific adaptations for antihistamine and other therapies in these groups.
  • Future research directions are identified for optimizing CSU care in vulnerable individuals.

Conclusions:

  • CSU management requires population-specific approaches for children, pregnant women, and the elderly.
  • Addressing treatment gaps in these vulnerable groups is crucial for improving patient outcomes.
  • Further research is needed to establish definitive, evidence-based guidelines for CSU in special populations.

Keywords:
AgeChronic spontaneous urticariaElderlyPediatricPopulationsPregnancySpecialUrticaria

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