Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Riboswitches01:56

Riboswitches

8.1K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neoadjuvant Danburstotug (IMC-001) therapy in gastric, esophageal, and hepatocellular carcinoma: the NeoChance phase II study.

NPJ precision oncology·2026
Same author

Kilovoltage Energy Significantly Enhances the Therapeutic Efficacy of Low-Dose Radiation in a 3xTg-AD Mouse Model of Alzheimer's Disease.

International journal of molecular sciences·2026
Same author

Atomic-scale TEM characterization of dislocation-precipitate interaction mechanisms in a cold-worked Al-Cu-Mg-Si alloy.

Micron (Oxford, England : 1993)·2026
Same author

Determinants of birth preparedness and complication readiness among postpartum women in Bugembe, Jinja City, Eastern Uganda: a community-based cross-sectional study.

BMC pregnancy and childbirth·2026
Same author

Impact of Intravenous Lidocaine, Dexmedetomidine, and Intrathecal Morphine on Metastasis-Related Biomarkers and Cellular Immune Profiles in Colorectal Surgery: A Prospective, Randomized Controlled Trial.

Anesthesia and analgesia·2026
Same author

Intratumoral T<sub>reg</sub> cell ablation elicits NK cell-mediated control of CD8 T cell-resistant tumors.

Science immunology·2026
Same journal

Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates.

Angewandte Chemie (International ed. in English)·2026
Same journal

Sequential H<sub>2</sub>S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy.

Angewandte Chemie (International ed. in English)·2026
Same journal

Quantitative Active Hydrogen Modulation via Mastering Interfacial Water Over Single Rare Earth Atom on Copper for NO<sub>3</sub> <sup>-</sup>-to-NH<sub>3</sub> Electroreduction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Unveiling the Role of Hydroxyls on Catalyst Surface in CO<sub>2</sub> Hydrogenation Reaction.

Angewandte Chemie (International ed. in English)·2026
Same journal

Strain-Release Pentafluorosulfanylation of Carbonyl-Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF<sub>5</sub>-Containing Oxa[2.1.1]bicyclohexanes.

Angewandte Chemie (International ed. in English)·2026
Same journal

Quantum Spin-1/2 Rings Built From [2]Triangulene Molecular Units.

Angewandte Chemie (International ed. in English)·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.2K

Stimuli-Responsive Molecular Duplexes Displaying Duplex-to-Duplex Switching.

Seungwon Lee1, Geunmoo Song1, Kyu-Sung Jeong1

  • 1Department of Chemistry, Yonsei University, Seoul, 03722, Republic of Korea.

Angewandte Chemie (International Ed. in English)
|June 27, 2024
PubMed
Summary
This summary is machine-generated.

Researchers synthesized stable molecular duplexes from indolocarbazole-pyridine oligomers. These duplexes exhibit temperature-controlled switching between hydrated and anhydrous forms, demonstrating potential for smart materials.

Keywords:
FoldamersHelical structuresHydrogen bondsSwitchingSynthetic duplex

More Related Videos

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
07:44

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes

Published on: July 6, 2016

11.1K
Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

1.4K

Related Experiment Videos

Last Updated: Jun 22, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.2K
Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes
07:44

Synthesis of Wavelength-shifting DNA Hybridization Probes by Using Photostable Cyanine Dyes

Published on: July 6, 2016

11.1K
Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction
03:38

Aptamer-Based Target Detection Facilitated by a 3-Stage G-Quadruplex Isothermal Exponential Amplification Reaction

Published on: October 6, 2022

1.4K

Area of Science:

  • Supramolecular chemistry
  • Organic materials science

Background:

  • Synthetic duplexes offer potential for biomimicry and advanced materials.
  • Indolocarbazole-pyridine (I-P) oligomers can form stable molecular structures.

Purpose of the Study:

  • To synthesize and characterize stimuli-responsive molecular duplexes from I-P oligomers.
  • To investigate the structural and responsive properties of these duplexes to water and temperature.

Main Methods:

  • Synthesis of indolocarbazole-pyridine oligomers.
  • Characterization of duplex structures using spectroscopic and thermodynamic methods.
  • Investigation of stimuli-responsive behavior (hydration, temperature-induced switching).

Main Results:

  • Novel nonclassical helical duplexes stabilized by I-P hydrogen bonds were formed.
  • The duplex 6₂ (11-mer)₂ exhibited high stability (ΔG≠=22.0 kcal·mol⁻¹) in anhydrous solvents.
  • Addition of water led to a hydrated duplex with high positive cooperativity (Hill coefficient n=6.1).
  • Reversible switching between anhydrous and hydrated duplexes was achieved by temperature control.
  • Temperature-dependent reversible switching between hetero- and homo-duplexes was observed with changes in emission signals.

Conclusions:

  • The synthesized I-P molecular duplexes demonstrate remarkable stability and stimuli-responsive behavior.
  • These duplexes can undergo reversible transformations triggered by water and temperature.
  • The findings highlight the potential of these molecular duplexes for developing supramolecular smart materials and responsive systems.