Related Experiment Video
Updated: Jun 22, 2025

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
Published on: May 4, 2020
Childhood outcomes following discharge from a referral bronchopulmonary dysplasia program
Katharine P Callahan1,2,3, Kathryn Farrell4, Kathleen Gibbs5,4
1Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. callahankp@chop.edu.
Insights
Children with severe bronchopulmonary dysplasia (BPD) face significant health and developmental challenges. These morbidities impact quality of life, with developmental issues becoming more prominent over time.
Area of Science:
- Pediatric Pulmonology
- Neonatology
- Child Development
Background:
- Bronchopulmonary dysplasia (BPD) is a chronic lung disease in infants.
- Severe BPD requires specialized quaternary care.
- Long-term outcomes for severe BPD are not fully understood.
Purpose of the Study:
- To profile health, development, and quality of life in children with severe BPD.
- To assess outcomes for children discharged from a quaternary BPD referral program.
- To identify correlations between morbidities and quality of life.
Main Methods:
- Cross-sectional study design.
- Telephone interviews with 282 families.
- Children aged 18 months to 11 years with severe BPD.
Main Results:
- Respiratory morbidities were prevalent; 42% required tracheostomy.
- Developmental morbidities were significant, with 97% needing individualized educational plans.
- Health and quality of life correlated with respiratory morbidity severity; developmental issues worsened over time.
Conclusions:
- Children referred to quaternary BPD programs experience severe respiratory and developmental morbidities.
- Outcomes suggest a greater burden of disease than previously reported.
- Developmental morbidities increasingly impact quality of life in this population.
Objectives:
The primary objective of this study was to profile the childhood health, development, and health-related quality of life (HR QoL) for children with the most severe bronchopulmonary dysplasia (BPD), those discharged from a quaternary referral program.
Study Design:
We collected cross-sectional data through telephone interviews with 282 families of children ages 18 months to 11 years who had been discharged from a BPD referral program.
Results:
Respiratory morbidities were near universal, with 42% of children ever having required a tracheostomy and severity of these morbidities correlated with parent-reported health and QoL. Developmental morbidities were also marked: 97% required an individualized educational plan. While respiratory morbidities and overall health improved over time, developmental morbidities were increasingly prominent, resulting in lower quality of life.
Conclusions:
Among children referred to a quaternary BPD program, respiratory and developmental morbidities are on numerous counts more severe than any reported in the literature.
Related Concept Videos
Pulmonary Cycle: Exhalation
Discharge Summary Forms
Here's a detailed look at the key components and guidelines for preparing a discharge summary:
Oppositional Defiant Disorder
Diagnostic Criteria and...
COPD: Management Using Bronchodilators and Corticosteroids
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-I: Introduction

