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Updated: Jun 22, 2025

Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Structure of the caffeine-pyrogallol complex: revisiting a pioneering structural analysis of a model pharmaceutical
Okba Al Rahal1, Michael Ferguson1, Cameron B Lennox1,2
1School of Chemistry, University of Birmingham, Edgbaston, B15 2TT, UK. t.friscic@bham.ac.uk.
Abstract:
The 1967 attempt of structural analysis of the solid-state complex of caffeine and pyrogallol was a pioneering structural investigation in the supramolecular chemistry of caffeine, of what today would easily be considered an archetype of a model pharmaceutical cocrystal. Re-investigating this historically important system demonstrates that this long overlooked complex is most likely a tetrahydrate with a different structure and composition than initially proposed, and provides the crystal structure of the anhydrous cocrystal.
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