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Protein-based layer-by-layer films for biomedical applications.

Muhammad Haseeb Iqbal1, Halima Kerdjoudj2, Fouzia Boulmedais1

  • 1Université de Strasbourg, CNRS, Institut Charles Sadron UPR 22, Strasbourg Cedex 2 67034 France haseebntu1@gmail.com fouzia.boulmedais@ics-cnrs.unistra.fr.

Chemical Science
|June 28, 2024
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Summary
This summary is machine-generated.

Surface engineering with protein-based layer-by-layer (LbL) films enhances biomaterial integration and prevents infections. This versatile method controls cell fate for various biomedical applications.

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Area of Science:

  • Biomaterials Science
  • Surface Engineering
  • Nanotechnology

Background:

  • Surface properties of biomaterials are critical for successful integration, influencing cell colonization and preventing adverse responses like fibrosis and bacterial infection.
  • The layer-by-layer (LbL) coating technique offers a versatile and simple method for surface functionalization at room temperature in aqueous media.
  • Proteins possess intrinsic biological properties that can be leveraged to control cellular behavior and tissue responses.

Purpose of the Study:

  • To review the application of protein-based LbL films in addressing key biomedical challenges.
  • To highlight the potential of LbL coatings for controlling mammalian and bacterial cell interactions.
  • To explore the use of protein-based LbL films in tissue engineering and drug delivery.

Main Methods:

  • The article focuses on the layer-by-layer (LbL) coating technique, involving the alternating deposition of macromolecules.
  • Emphasis is placed on utilizing protein-based films for surface functionalization.
  • The review covers applications in various biomedical domains, excluding biosensing and electrochemical aspects.

Main Results:

  • Protein-based LbL films demonstrate significant potential for controlling bacterial and mammalian cell fate.
  • These engineered surfaces can promote tissue-specific cell colonization and prevent undesirable outcomes.
  • The LbL approach enables tailored surface properties for diverse biomedical applications.

Conclusions:

  • Protein-based LbL films are a powerful tool for surface engineering of biomaterials.
  • This technique offers versatile solutions for challenges in infection control, blood compatibility, cell adhesion, and tissue regeneration.
  • The strategic use of protein-based LbL coatings can significantly improve the performance of biomaterials in clinical settings.