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Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
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Research progress of microRNA in spinal cord injury

Dong-Min Wei1, Rui Fang2, Zhi-Zhong Deng1

  • 1Medical College of Yan'an University, Yan'an 716000, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|June 28, 2024
PubMed

Insights

MicroRNAs (miRNAs) are crucial in spinal cord injury (SCI) by regulating inflammation, cell death, and nerve repair. This review explores miRNA roles and therapeutic potential for SCI treatment.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Spinal cord injury (SCI) is a debilitating condition with complex mechanisms.
  • MicroRNAs (miRNAs) are key regulators in the central nervous system's response to injury.
  • miRNAs interact with other non-coding RNAs like lncRNAs and circRNAs in SCI pathophysiology.

Purpose of the Study:

  • To summarize miRNA expression changes post-SCI.
  • To review miRNA targeting mechanisms in SCI.
  • To discuss the current status of miRNA-targeted therapies for SCI.

Main Methods:

  • Literature review of studies on miRNA expression and function in SCI.
  • Analysis of miRNA-mediated regulatory pathways.
  • Examination of preclinical and clinical research on miRNA-based therapeutics.

Main Results:

  • miRNAs significantly alter following SCI, impacting key processes.
  • miRNAs regulate inflammatory responses, oxidative stress, axonal regeneration, and apoptosis.
  • Interactions between miRNAs, lncRNAs, and circRNAs are critical in SCI.

Conclusions:

  • miRNAs represent promising therapeutic targets for SCI.
  • Understanding miRNA mechanisms offers new avenues for SCI treatment.
  • Further research into miRNA-targeted drugs is essential for clinical application.

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