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Impacts of Multiple and One-time Root Canal Therapy on Immune and Inflammatory Response in Endodontic Patients
Background:
Root canal therapy is a widely adopted clinical approach for managing endodontic diseases. However, patients undergoing multiple root canal treatments face an increased risk of reinfection, complicating treatment outcomes.
Objective:
This study aims to evaluate the effects of both multiple and one-time root canal therapy on the immune and inflammatory responses in endodontic patients.
Design:
A randomized controlled study was conducted.
Setting:
The research was carried out at the 8th People's Hospital of Shanghai.
Participants:
A total of 100 endodontic patients admitted to the Stomatology Department of the hospital from January 2021 to December 2022 were randomly allocated to either the study group or the control group, with each group consisting of 50 cases.
Interventions:
The control group received multiple root canal therapy, while the study group underwent one-time root canal treatment.
Primary Outcome Measures:
(1) Clinical treatment effectiveness, (2) pain intensity, (3) levels of inflammatory factors, (4) oral immune factor levels, (5) oral health-related quality of life, and (6) occurrence of adverse reactions were assessed.
Results:
The study group demonstrated a significantly higher total effective rate compared to the control group (P < .05). Post-treatment, the study group exhibited lower pain scores, reduced levels of inflammatory factors, improved oral health-related quality of life, and fewer adverse reactions compared to the control group (P < .05). Additionally, the study group showed elevated levels of lysozyme, human β-defensin 2, and secretory Immunoglobulin A compared to the control group (P < .05).
Conclusions:
One-time root canal therapy in endodontic patients yields superior outcomes, effectively reducing adverse reactions and inflammatory factor levels, enhancing chewing function, alleviating pain, and demonstrating clinical utility. This study underscores the importance and efficacy of adopting a one-time root canal treatment approach in endodontic practice.
