Prediction of Bone Remodeling in Rat Caudal Vertebrae Based on Fluid-Solid Coupling Simulation
Sen Zhao1, Yan Gao2,3, Huijie Leng4
1Biomechanics Lab, Department of Mechanics, School of Aerospace Engineering, Beijing Institute of Technology, Beijing, 100081, People's Republic of China.
Annals of Biomedical Engineering
|June 28, 2024
Summary
Mechanical stimulation impacts bone remodeling. This study found wall fluid shear stress (FSS) more accurately predicts cancellous bone resorption than strain energy density (SED), highlighting fluid flow
Area of Science:
- Biomechanical Engineering
- Orthopedics
- Cellular Biology
Background:
- Mechanical stimulation influences bone formation and remodeling.
- Strain energy density (SED) is commonly used to predict bone remodeling.
- The role of wall fluid shear stress (FSS) in bone remodeling is less understood.
Purpose of the Study:
- To compare the predictive accuracy of SED and wall FSS for bone remodeling.
- To investigate the impact of fluid flow on bone resorption in cancellous bone.
Main Methods:
- Fluid-solid coupling numerical simulation was employed.
- A 3D model of rat caudal vertebrae was created from micro-CT images.
- Mechanical stretching was applied to different groups (control, 1 Hz, 10 Hz).
Main Results:
- SED values increased with porosity; wall FSS values decreased with porosity.
- Wall FSS showed higher predictive accuracy for cancellous bone resorption compared to SED.
- Fluid flow within cancellous bone spaces significantly impacts bone resorption.
Conclusions:
- Wall FSS is a critical factor in predicting bone resorption, particularly in cancellous bone.
- Fluid flow dynamics within bone marrow play a significant role in bone remodeling.
- Findings provide theoretical support for understanding bone structure evolution under mechanical loading.
