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Updated: Jun 22, 2025

Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos
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Author Spotlight: Optogenetic Inhibition of Rho1-Mediated Actomyosin Contractility Coupled with Measurement of Epithelial Tension in Drosophila Embryos

Published on: April 14, 2023

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The centrosomal protein FGFR1OP controls myosin function in murine intestinal epithelial cells

Tihana Trsan1, Vincent Peng1, Chirag Krishna2

  • 1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.

Developmental Cell
|June 28, 2024
PubMed
Summary

FGFR1OP gene deficiency disrupts intestinal epithelial integrity, increasing susceptibility to inflammatory bowel disease like Crohn's disease. This research highlights FGFR1OP's role in maintaining gut health and epithelial repair.

Keywords:
FGFR1OPadhesionautoimmunitycentrosomecytoskeletondesmosomeepithelial cellsinflammatory bowel diseasenon-muscle myosin

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