Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantifying cortical lesions in multiple sclerosis MRI datasets using multi-contrast post-processing and deep learning.

Communications medicine·2026

Same author

Phase 2 Futility Trials in Alzheimer Disease and Mild Cognitive Impairment: A Cohort Analysis of the ADNI Data Set.

Neurology·2026

Same author

Mediation Analysis Between Brain Age, Disease-Modifying Factors, and Disability and Cognitive Performance in Multiple Sclerosis.

Neurology·2026

Same author

Decreased amyloid-related structure-function coupling in preclinical Alzheimer's disease.

Communications medicine·2026

Same author

The constrained brain in multiple sclerosis: Cognitive impairment is related to network-specific coupling of structural and functional connectivity.

Multiple sclerosis journal - experimental, translational and clinical·2026

Same author

An automated quantitative report for multiple sclerosis using only 3D T2-fluid-attenuated inversion recovery MRI.

Neuroradiology·2026

Search research articles

Related Experiment Video

Updated: May 12, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Network Analysis in Multiple Sclerosis and Related Disorders.

Giuseppe Pontillo¹, Mar Barrantes Cepas², Tommy A A Broeders²

¹MS Center Amsterdam, Anatomy and Neurosciences, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, Postbus 7057, 1007 MB, Amsterdam, The Netherlands; MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, Postbus 7057, 1007 MB, Amsterdam, The Netherlands.

Neuroimaging Clinics of North America

|June 28, 2024

Summary

This summary is machine-generated.

Multiple sclerosis (MS) is a complex brain disorder affecting neuronal pathways. This review explores network neuroscience innovations for understanding MS as a network disorder.

Keywords:

Brain networks Diffusion MR imaging Functional MR imaging Graph theory Multiple sclerosis Structural MR imaging

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Area of Science:

Neuroscience
Neurology
Medical Imaging

Background:

Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease impacting the central nervous system.
MS pathology is characterized by demyelination, leading to disrupted structural and functional neuronal connectivity.
Clinical manifestations include significant disability and cognitive impairment.

Purpose of the Study:

To review recent advancements in network neuroscience applied to multiple sclerosis.
To highlight the understanding of MS as a network disorder.

Main Methods:

Review of current literature on network neuroscience in MS.
Analysis of studies investigating structural and functional brain connectivity in MS patients.

Main Results:

MS involves extensive structural disconnection in critical brain network hubs, such as the thalamus.
Functional network reorganization in MS is often associated with diminished clinical functioning.
These findings support the conceptualization of MS as a network disorder.

Conclusions:

Network neuroscience offers valuable insights into the complex pathophysiology of MS.
Understanding MS through a network lens can potentially lead to improved diagnostic and therapeutic strategies.