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Related Concept Videos

Insomnia01:27

Insomnia

82
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
82
Management of Insomnia01:19

Management of Insomnia

243
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

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Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.3K

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Related Experiment Video

Updated: Jun 22, 2025

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Insomnia Subtypes Have Differentiating Deviations in Brain Structural Connectivity.

Tom Bresser1, Tessa F Blanken2, Siemon C de Lange3

  • 1Netherlands Institute for Neuroscience, Department of Sleep and Cognition, Amsterdam, the Netherlands; Department of Integrative Neurophysiology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Biological Psychiatry
|June 29, 2024
PubMed
Summary

Different insomnia subtypes show unique brain connectivity patterns. Understanding these differences in structural brain connectivity is key to uncovering insomnia vulnerability and developing targeted treatments.

Keywords:
ConnectivityHeterogeneityInsomniaNeuroimagingSubtypesWhite matter

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Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Psychiatry

Background:

  • Insomnia disorder is a prevalent sleep disorder with poorly understood brain mechanisms.
  • Heterogeneity within the insomnia population may hinder the identification of specific brain circuits involved.
  • Recent validation of insomnia subtypes necessitates investigation into their distinct neural underpinnings.

Purpose of the Study:

  • To investigate differences in structural brain connectivity among validated insomnia subtypes.
  • To determine if distinct insomnia subtypes exhibit unique patterns of altered brain connectivity.

Main Methods:

  • Harmonized structural and diffusion-weighted MRI data from 4 independent studies.
  • 204 insomnia participants were classified into 5 subtypes based on mood and personality traits.
  • Linear regression analyzed group differences in structural connectivity (e.g., fractional anisotropy) across 3 atlases.

Main Results:

  • Insomnia subtypes displayed differential structural connectivity profiles within various functional networks.
  • Four of five subtypes showed significant specificity in connectivity deviation profiles.
  • Connectivity deviation profiles were significant across different brain parcellation resolutions (p = .001 to .049).

Conclusions:

  • Distinct insomnia subtypes present unique structural brain connectivity deviation profiles.
  • Subtyping insomnia is crucial for advancing the understanding of brain mechanisms underlying insomnia vulnerability.
  • These findings may inform the development of more personalized insomnia treatments.