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Updated: Jun 22, 2025

Characterizing Cellular Proteins with In-cell Fast Photochemical Oxidation of Proteins
Published on: March 11, 2020
[Consensus update of the POPI tool]
Wala Ammor1, Christele Gras Le Guen2, François Angoulvant3
1Pharmacie, Nantes université, CHU de Nantes, 44000 Nantes, France.
Insights
The updated POPI tool now helps detect inappropriate paediatric drug prescriptions and omissions. This revised tool ensures safer medication use in children by incorporating current medical guidelines and expert consensus.
Area of Science:
- Pediatric pharmacology
- Medication safety research
- Health informatics
Context:
- Medication errors are a significant cause of iatrogenic harm in children.
- The original POPI (Prescription Omissions and Prescription Inappropriateness) tool was developed in 2014 to address these issues.
- There is a need to update paediatric medication assessment tools to reflect current clinical practice and guidelines.
Purpose:
- To update the POPI tool for French paediatric practice.
- To incorporate current recommendations from learned societies and national bodies.
- To enhance the detection of inappropriate drug prescriptions and prescription omissions in children.
Summary:
- A two-round Delphi method involving 20 French healthcare professionals (pharmacists and doctors) was employed.
- Criteria were refined based on expert consensus, with specific agreement thresholds set for retention.
- The updated POPI tool now comprises 166 validated criteria across eight categories, supported by bibliographical references.
Impact:
- The revised POPI tool provides a comprehensive framework for assessing paediatric prescriptions.
- It aims to improve medication safety and reduce iatrogenic errors in paediatric care.
- The updated tool is available for evaluating paediatric medication appropriateness in clinical settings.
Abstract:
Medication errors are one of the causes of iatrogenic medication use in children. The POPI tool for detecting inappropriate drug prescriptions and prescription omissions in paediatrics was the first tool to be published in this field in 2014. Our aim was to update the POPI tool for French use based on current recommendations and practice. Criteria were removed, updated or added based on recommendations from learned societies and national bodies. The two-round Delphi method was used to reach a consensus of experts. The level of agreement of the healthcare professionals' proposals was rated on a 9-point Likert scale. In the first round, only proposals with a median agreement of 7 to 9 and an agreement of more than 65% were retained. In the second round, only those with a median agreement of 7 to 9 and over 75% agreement were retained. The POPI tool now includes eight categories (various, infectiology, gastroenterology, pneumonology, dermatology, neurology/pedopsychiatry, haematology and excipients). All the criteria were supported by bibliographical references. They were submitted to 20 French healthcare professionals: 9 pharmacists and 11 doctors (17 hospital-based and 3 self-employed). After two rounds of Delphi testing, 166 criteria were retained and validated (111 inappropriate prescriptions and 55 omissions). In conclusion, this study made it possible to update the POPI tool, which is still available for assessing paediatric prescriptions.
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