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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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What is the Immune System?01:38

What is the Immune System?

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Overview
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
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Overview of Systemic Autoinflammatory Diseases.

Samira Nazzar Romero1, Deborah McCurdy2

  • 1Division of Rheumatology, Nemours Children's Health, University of Central Florida College of Medicine.

Advances in Pediatrics
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Systemic autoinflammatory diseases (SAID) are innate immune system disorders. Early recognition of SAID clinical signs is crucial for diagnosis and management, with new therapies in development.

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AutoinflammationAutoinflammatory diseasesInflammasomeInterferonopathyNF-κBPeriodic feversRecurrent feversTumor necrosis factor

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Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Systemic autoinflammatory diseases (SAID) represent a spectrum of innate immune system disorders.
  • The classification and understanding of SAID are evolving with new discoveries.
  • Clinical recognition is key for timely diagnosis and effective patient management.

Purpose of the Study:

  • To provide an overview of the current understanding of Systemic Autoinflammatory Diseases.
  • To highlight the importance of recognizing SAID clinical manifestations.
  • To discuss the ongoing advancements in the field, including potential therapies.

Main Methods:

  • Review of current literature on SAID.
  • Analysis of evolving definitions and classifications.
  • Discussion of clinical features and diagnostic approaches.

Main Results:

  • SAID are a diverse group of immune-related conditions.
  • Changes in SAID definition and classification reflect ongoing research.
  • Clinical manifestations vary, necessitating expert recognition.

Conclusions:

  • Early diagnosis and management of SAID are critical.
  • The field of SAID is dynamic, with continuous updates in understanding.
  • Emerging therapies offer hope for improved patient outcomes.