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Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
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Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: Basing Care on Physiology

Paula Dias Maia1,2, Steven H Abman2,3, Erica Mandell1,2

  • 1Section of Neonatology, Department of Pediatrics, University of Colorado Anschutz School of Medicine and Children's Hospital Colorado, Aurora, CO.

Neoreviews
|June 30, 2024
PubMed

Insights

Bronchopulmonary dysplasia (BPD) with pulmonary hypertension (PH) presents diverse phenotypes. Tailoring treatments to individual infant physiology is crucial for improving outcomes in premature infants with BPD-PH.

Area of Science:

  • Neonatology
  • Pediatric Pulmonology
  • Developmental Biology

Background:

  • Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants.
  • Pulmonary vascular disease and pulmonary hypertension (PH) are significant contributors to BPD.
  • BPD often involves multisystem comorbidities affecting preterm infants.

Purpose of the Study:

  • To highlight the importance of recognizing diverse BPD-PH phenotypes.
  • To emphasize the need for individualized management strategies.
  • To improve short- and long-term outcomes for infants with BPD-PH.

Main Methods:

  • Review of clinical presentations and pathophysiological mechanisms of BPD-PH.
  • Analysis of factors influencing patient outcomes.
  • Discussion of individualized therapeutic approaches.

Main Results:

  • BPD-PH encompasses a spectrum of clinical phenotypes.
  • Specific physiologies require tailored therapeutic interventions.
  • Multisystem comorbidities are common in BPD-PH.

Conclusions:

  • Recognizing the "BPD-PH umbrella" is essential for effective clinical care.
  • Individualized management, considering risk factors and phenotype, is paramount.
  • Optimizing care for preterm infants with BPD-PH necessitates a personalized approach.

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