Related Experiment Video

Updated: Jun 22, 2025

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions
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Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

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14-3-3 Family of Proteins: Biological Implications, Molecular Interactions, and Potential Intervention in Cancer,

Zheng Yao Low1, Ashley Jia Wen Yip1, Alvin Man Lung Chan2

  • 1School of Science, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia.

Journal of Cellular Biochemistry
|July 1, 2024
PubMed

Insights

The 14-3-3 proteins are crucial for cell regulation but linked to diseases like cancer and viral infections. Understanding their interactions may reveal future therapeutic targets for these conditions.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • The 14-3-3 proteins are conserved acidic eukaryotic proteins involved in numerous cellular processes.
  • Their functions include cell cycle regulation and gene transcription control.
  • Dysregulation of 14-3-3 proteins is implicated in cancer, neurodegenerative diseases, and viral infections.

Purpose of the Study:

  • To review the structure, properties, and biological functions of 14-3-3 proteins.
  • To discuss the implications of 14-3-3 proteins in diseases such as cancer, neurodegeneration, and viral infections.
  • To explore the potential of 14-3-3 proteins as therapeutic targets.

Main Methods:

  • Literature review of existing studies on 14-3-3 proteins.
  • Analysis of the role of 14-3-3 proteins in various disease contexts.
  • Discussion of therapeutic strategies targeting 14-3-3 proteins.

Main Results:

  • 14-3-3 proteins exhibit an inverse correlation in cancer and neurodegenerative diseases.
  • Viruses, including SARS-CoV-2, manipulate 14-3-3 proteins for replication.
  • The review covers the known functions and disease associations of 14-3-3 proteins.

Conclusions:

  • 14-3-3 proteins are vital signaling mediators with significant roles in health and disease.
  • Targeting 14-3-3 proteins presents a promising therapeutic avenue for cancers, neurodegenerative disorders, and viral infections.
  • Further research into 14-3-3 protein interactions is crucial for developing novel treatments.
Keywords:
AlzheimerCOVID‐19ParkinsonSARS‐CoV‐2cancercell‐deathvirus

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