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  3. Spontaneous Cerebrovascular Reactivity At Rest In Older Adults With And Without Mild Cognitive Impairment And Memory Deficits.
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  3. Spontaneous Cerebrovascular Reactivity At Rest In Older Adults With And Without Mild Cognitive Impairment And Memory Deficits.

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Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory

Allison C Engstrom1, John Paul Alitin2, Arunima Kapoor1

  • 1Department of Psychological Science, University of California, Irvine, Irvine, CA, USA.

Medrxiv : the Preprint Server for Health Sciences
|July 1, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Cerebrovascular reactivity (CVR) deficits in the parahippocampal gyrus are linked to mild cognitive impairment (MCI) and memory loss in older adults. This suggests microvascular dysfunction contributes to cognitive decline.

Keywords:
amnestic mild cognitive impairmentmemory impairmentmild cognitive impairmentspontaneous cerebrovascular reactivity

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Area of Science:

  • Neuroscience
  • Gerontology
  • Vascular Biology

Background:

  • Mild cognitive impairment (MCI) in older adults is associated with cerebrovascular reactivity (CVR) deficits.
  • CVR may serve as a biomarker for vascular contributions to MCI.
  • This study investigates the link between spontaneous CVR, MCI, and memory impairment.

Purpose of the Study:

  • To determine if spontaneous CVR is associated with MCI in older adults.
  • To explore the relationship between CVR and memory performance.
  • To identify potential microvascular contributions to cognitive decline.

Main Methods:

  • 161 older adults without dementia or major neurological/psychiatric disorders were enrolled.
  • Participants underwent clinical assessments, cognitive testing, Alzheimer's biomarker analysis, and brain MRI.
  • Spontaneous CVR was measured during a 5-minute resting state.

    • Main Results:

    • Whole brain CVR showed a negative association with age but not MCI.
    • Lower CVR in the parahippocampal gyrus (PHG) was observed in participants with MCI.
    • Reduced PHG CVR correlated with poorer memory test performance, independent of Alzheimer's biomarkers and vascular risk factors.

    Conclusions:

    • Spontaneous CVR deficits in the PHG are present in older adults with MCI and memory impairment.
    • These findings suggest medial temporal lobe microvascular dysfunction plays a role in cognitive decline.
    • CVR in the PHG may be a sensitive indicator of early-stage cognitive impairment.