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Alpha-Tocopherol Levels in Patients With Dentigerous Cysts: A Cross-Sectional Study
Nausathkhan Ubayathulla1,2, Muthusekar M R1, Pratibha Ramani3
1Oral and Maxillofacial Surgery, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, IND.
Cureus
|July 1, 2024
Summary
Patients with dentigerous cysts (DC) have significantly lower serum vitamin E (alpha-tocopherol) levels compared to healthy individuals. This reduction may influence cyst aggressiveness, warranting further research into vitamin E supplementation.
Area of Science:
- Oral and Maxillofacial Surgery
- Nutritional Biochemistry
- Dermatology
Background:
- Dentigerous cysts (DC) are fluid-filled lesions developing from tooth eruption disturbances.
- The etiology and clinical behavior of DCs necessitate further investigation.
- Understanding serum markers associated with DC development is crucial for diagnosis and management.
Purpose of the Study:
- To quantify serum alpha-tocopherol (vitamin E) levels in patients diagnosed with dentigerous cysts.
- To compare these levels with those in a control group of healthy individuals.
Main Methods:
- A case-control study involving 34 participants (17 DC patients, 17 healthy controls).
- Serum samples were collected for biochemical analysis.
- Alpha-tocopherol concentration was measured and reported in mg/mL.
Main Results:
- Patients with dentigerous cysts exhibited significantly lower mean serum vitamin E levels (5.29 ± 1.01 mg/mL) compared to healthy controls (12.08 ± 1.92 mg/mL).
- The difference in vitamin E levels was statistically significant (p<0.0001).
Conclusions:
- Reduced serum vitamin E concentration is associated with dentigerous cysts.
- Lower vitamin E levels may correlate with increased cyst volume and lesion aggressiveness.
- Future research should explore the potential therapeutic role of vitamin E supplementation in managing DCs.
