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Updated: Jun 22, 2025

A Web Tool for Generating High Quality Machine-readable Biological Pathways
Published on: February 8, 2017
Perspectives on computational modeling of biological systems and the significance of the SysMod community
Bhanwar Lal Puniya1, Meghna Verma2, Chiara Damiani3
1Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, United States.
Motivation:
In recent years, applying computational modeling to systems biology has caused a substantial surge in both discovery and practical applications and a significant shift in our understanding of the complexity inherent in biological systems.
Results:
In this perspective article, we briefly overview computational modeling in biology, highlighting recent advancements such as multi-scale modeling due to the omics revolution, single-cell technology, and integration of artificial intelligence and machine learning approaches. We also discuss the primary challenges faced: integration, standardization, model complexity, scalability, and interdisciplinary collaboration. Lastly, we highlight the contribution made by the Computational Modeling of Biological Systems (SysMod) Community of Special Interest (COSI) associated with the International Society of Computational Biology (ISCB) in driving progress within this rapidly evolving field through community engagement (via both in person and virtual meetings, social media interactions), webinars, and conferences.
Availability And Implementation:
Additional information about SysMod is available at https://sysmod.info.
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