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Pulmonary disease in the immunocompromised host (2).

W R Wilson, F R Cockerill, E C Rosenow

    Mayo Clinic Proceedings
    |September 1, 1985
    PubMed
    Summary

    Diagnosing pulmonary disease in immunocompromised patients (ICH) often requires invasive procedures like open-lung biopsy. Bronchoalveolar lavage shows promise for diagnosing infections in those with acquired immunodeficiency syndrome (AIDS).

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    Area of Science:

    • Pulmonology
    • Infectious Diseases
    • Immunology

    Background:

    • Pulmonary disease is a significant concern in immunocompromised hosts (ICH).
    • A wide range of infectious agents can cause pulmonary disease in ICH.
    • Identifying the cause of pulmonary infiltrates in ICH is clinically challenging.

    Purpose of the Study:

    • To review infections associated with pulmonary infiltrates in ICH.
    • To discuss diagnostic approaches for infectious and noninfectious pulmonary conditions in ICH.
    • To evaluate the utility of bronchoalveolar lavage in diagnosing pulmonary disease in ICH.

    Main Methods:

    • Review of existing literature on pulmonary disease in ICH.
    • Analysis of diagnostic procedures, including physical findings, laboratory tests, and invasive methods.
    • Specific focus on bronchoalveolar lavage in patients with acquired immunodeficiency syndrome (AIDS).

    Main Results:

    • While specific defects may predispose to certain infections, any agent can affect ICH.
    • Clinical findings offer clues, but invasive procedures are often essential for diagnosis.
    • Bronchoalveolar lavage is useful for diagnosing pulmonary disease in patients with AIDS.

    Conclusions:

    • Accurate diagnosis of pulmonary disease in ICH frequently necessitates invasive procedures.
    • Bronchoalveolar lavage is a valuable tool for diagnosing pulmonary disease in AIDS patients.
    • Further research is needed to establish the reliability of bronchoalveolar lavage in non-AIDS ICH.

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