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Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

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Common variable immunodeficiency associated enteropathy: A diagnostic enigma in developing countries.

Muhammad Aftab Hassan¹, Muhammad Hussain¹, Dawood Ahmad¹

¹Department of Immunology, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.

JPMA. the Journal of the Pakistan Medical Association

|July 1, 2024

Summary

This summary is machine-generated.

Common variable immunodeficiency (CVID) is a prevalent disorder causing recurrent infections and increased cancer risk. Early immunological workup is crucial for timely diagnosis and management of CVID complications.

Keywords:

Common Variable Immunodeficiency, Enteropathy, Primary Immunodeficiency.

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Area of Science:

Immunology
Clinical Medicine

Background:

Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency.
It presents with diverse phenotypes and etiologies, characterized by hypogammaglobulinaemia and impaired T cell function.
This leads to an increased susceptibility to recurrent infections, autoimmunity, enteropathy, and malignancies.

Observation:

The 'Variable' in CVID highlights significant heterogeneity in clinical presentations.
Diagnosis is challenging due to the wide spectrum of manifestations and its nature as a diagnosis of exclusion.
CVID and its complications, though common, are underrepresented in local literature.

Findings:

The case underscores the critical need for a systematic immunological evaluation in suspected immunodeficiency cases.
Timely diagnosis and intervention are essential to mitigate severe health consequences.

Implications:

Highlighting the importance of CVID in clinical practice and medical literature.
Emphasizing the role of early and thorough immunological assessment to prevent significant morbidity and mortality associated with CVID.