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Updated: Jun 22, 2025
A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection
Published on: January 7, 2019
Using the Zebrafish Larval Model of Infection to Investigate Antibiotic Efficacy and Combination Treatments Against
Amy K Tooke1,2, Simon J Foster3,4,5
1School of Biosciences, University of Sheffield, Sheffield, UK.
Abstract:
There is an increasing need for new treatment regimens to combat antibiotic-resistant strains of bacteria. Staphylococcus aureus is a clinically important, opportunist pathogen that has developed resistance to a range of antibiotics. The zebrafish larval model of systemic disease has been increasingly utilized to elucidate S. aureus virulence mechanisms and host-pathogen interactions. Here, we outline how this model can be used to investigate the effects of different antibiotics alone and in combination against S. aureus.
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