Formation of a Metallomacrocycle Possessing Nitrogen Donors Assembled in the Cavity and Unique Water Clusters

2,2'-Bipyridyl (bpy) is widely used as a chelating unit for metal complexation but is not usually considered as a hydrogen-bonding unit. This is because the metal-free bpy units are usually in a transoid conformation, and the two nitrogen lone pairs are pointed to the opposite sides. We now report a metallomacrocycle whose three metal-free bpy units are in a cisoid conformation and are fixed in the cavity. The complexation of nickel(II) only at the salen units of the triangular bpytrisalen ligand produced this rigid and planar macrocycle. Its cavity is surrounded by hydrogen-bond acceptors (N of bpy and O of salen), and it was found that unique pentagonal prism clusters of water molecules templated by the cavity were formed in the crystal. This study has not only increased the variation of the synthetic methodologies of multinuclear complexes but has also provided the structural platform on which multiple bpy units exert hydrogen-bonding functions.