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Serial quantitative imaging with 99Tcm-DTPA in pediatric renal transplantation
Clinical Nephrology
|October 1, 1979
Summary
Renal scintigraphy using 99Tcm-DTPA effectively detects decreased renal perfusion in pediatric kidney transplant rejection. This imaging technique aids early diagnosis and prevents unnecessary treatments, showing high diagnostic value.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Nuclear Medicine
Background:
- Pediatric kidney transplantation is crucial for end-stage renal disease.
- Early detection of rejection is vital for graft survival.
- Renal perfusion assessment aids in diagnosing transplant complications.
Purpose of the Study:
- To evaluate the utility of sequential renal scintigraphy with 99Tcm-DTPA.
- To assess renal perfusion for early diagnosis of rejection in pediatric renal transplant recipients.
- To determine the role of scintigraphy in guiding treatment decisions.
Main Methods:
- Performed 358 renal imaging studies with 99Tcm-DTPA quantitation of renal perfusion.
- Studied 22 children (aged 6-15 years) with renal transplants.
- Analyzed scans for changes in renal perfusion correlating with clinical events.
Main Results:
- Decreased renal perfusion was observed in 58 of 62 scans during rejection episodes.
- Reduced perfusion was the sole rejection indicator in 6 episodes, often with acute tubular necrosis.
- Scans identified ureteric obstruction and lymphocoele, with no associated morbidity.
Conclusions:
- Sequential renal scintigraphy is valuable for early diagnosis of renal transplant rejection in children.
- Quantitation of renal perfusion aids in differentiating rejection from other complications.
- This imaging modality helps avoid unnecessary antirejection therapy.