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Mangiferin, a component of Mangifera indica leaf extracts, inhibits lipid synthesis in human sebocytes
Da-Min Jung1, Sangsoo Lee1, Eun-Mi Kim2
1Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon, Republic of Korea.
Abstract:
Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of Mangifera indica leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.
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