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Short-duration peripherally inserted central catheters do not alter viscoelastic parameters in healthy dogs
Leah Morris1, Angelica Galezowski1, Aylin Atilla1
1Faculty of Veterinary Medicine, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4 (Morris, Galezowski, Atilla, Menard); VCA Canada Calgary Animal Referral and Emergency Hospital, 7140 12th Street SE, Calgary, Alberta T2H 2Y4 (Morris).
Objective:
To determine if short-duration peripherally inserted central catheters (PICCs) cause a hypercoagulable state in healthy dogs, based on point-of-care viscoelastic coagulation monitor (VCM).
Animals:
Ten beagle dogs were randomly and equally allocated into control and PICC groups.
Procedure:
Control dogs had VCM analysis on whole blood following direct venipuncture before sedation (T0) and 2 h after sedation (T2). In the experimental group, a PICC was placed (medial saphenous or femoral vein) under sedation and removed after 4 h, with measurements before placement (T0) and 2 and 6 h after placement (T2 and T6, respectively). Parametric data were analyzed using 1-way ANOVA with Holm-Šídák test for multiple comparisons and paired or unpaired Student's t-test. Nonparametric data were analyzed using Friedman test with Dunn multiple comparison test for Wilcoxon matched-pairs signed-rank test, and Mann-Whitney U test for PICC group, control group, and to compare PICC versus control groups, respectively.
Results:
Clot formation time was longer at T2 versus T6 (P = 0.0342, but not clinically relevant) in the PICC group, with no significant differences between the PICC and control groups.
Conclusion And Clinical Relevance:
Short-term placement of a PICC line did not alter viscoelastic endpoints in healthy beagles.
