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Neuroimmune crosstalk : How mental stress fuels vascular inflammation

Ulrike Meyer-Lindemann1,2, Hendrik B Sager3,4

  • 1Department of Cardiology, German Heart Centre Munich, Technical University Munich, Lazarettstr. 36, 80636, Munich, Germany.

Herz
|July 2, 2024
PubMed

Insights

Mental stress significantly impacts cardiovascular disease by altering the immune system and vascular inflammation through neuroimmune interactions. Further research is needed to identify new therapeutic targets and refine treatment strategies for atherosclerosis.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Neuroscience

Background:

  • Cardiovascular diseases (CVDs) are a primary global cause of mortality.
  • Metabolic and inflammatory pathways are key drivers in CVD development and progression.
  • Emerging research highlights the critical role of inflammation in atherosclerosis.

Purpose of the Study:

  • To elucidate the mechanisms by which mental stress affects the immune system and vascular inflammation.
  • To explore the neuroimmune interactions underlying stress-induced cardiovascular risk.
  • To identify research gaps and future directions for combating inflammation in cardiovascular disease.

Main Methods:

  • Review of pre-clinical and clinical studies on mental stress and cardiovascular disease.
  • Analysis of neuroimmune pathways linking stress to vascular inflammation.
  • Examination of lifestyle-associated risk factors and their impact on the immune system.

Main Results:

  • Mental stress, both acute and chronic, modulates immune responses, particularly leukocyte function.
  • Neuroimmune interactions mediate the effects of stress on vascular inflammation.
  • Lifestyle factors significantly influence immune system alterations relevant to atherosclerosis.

Conclusions:

  • Mental stress is a significant factor in cardiovascular disease pathogenesis via immune system modulation.
  • Understanding neuroimmune interactions is crucial for developing targeted anti-inflammatory therapies.
  • Further research is essential to refine treatment strategies and identify patient responders for managing inflammation in cardiovascular disease.

Keywords:
Acute stressAnti-inflammatory agentsAtherosclerosisChronic stressNeuroimmune interactions

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