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Updated: Aug 12, 2026

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
Published on: November 10, 2011
Intracellular pathways of protein synthesis and secretion in the hepatocyte
Abstract:
The multiplicity of data summarized in this review indicate a variety of signals built into the intrinsic structure of secretory, membrane-associated, and lysosomal glycoproteins, which direct these complex molecules toward specific cellular organelles. Some of these signals (such as the NH2-terminal signal segment) are discarded when the appropriate transfer has been completed. Others are retained as a permanent intrinsic component of the molecule. Although evidence has been presented that the carbohydrate moieties of glycoproteins are not essential for secretion, they probably subserve a role in the interaction of glycoproteins with membrane receptors on intracellular organelles. Undoubtedly, other examples of permanent molecular signals will be described in the future, which will provide a comprehensive picture of the integrated transport activity of the membrane channels of the secretory pathway of the hepatocyte.
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