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Updated: Jul 14, 2026
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Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis (NASH) Resolution
Published on: April 16, 2019
Nonalcoholic fatty liver (NASH syndrome)
B J O'Connor1, B Kathamna, A S Tavill
1Division of Gastroenterology, Mount Sinai Medical Center, Cleveland, OH 44106-4198, USA.
The Gastroenterologist
|January 22, 1998
Summary
Nonalcoholic steatohepatitis (NASH) is a common fatty liver disease. Diagnosis relies on liver biopsy showing steatosis and inflammation, with weight loss and diet as primary treatments.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Nonalcoholic steatohepatitis (NASH) is a prevalent liver condition in adults.
- Clinical presentations range from asymptomatic liver enzyme elevation to cryptogenic cirrhosis.
- Risk factors include female gender, obesity, diabetes, and hyperlipidemia, though not all patients fit these profiles.
Purpose of the Study:
- To define Nonalcoholic steatohepatitis (NASH) and its diagnostic criteria.
- To outline current understanding of NASH pathogenesis and clinical associations.
- To review diagnostic modalities and current treatment strategies for NASH.
Main Methods:
- Diagnosis of NASH is confirmed by liver biopsy, identifying steatosis and inflammation.
- Fibrosis is a variable feature, assessed alongside steatosis and inflammation.
- Imaging techniques can detect steatosis but are less effective for evaluating fibrosis.
Main Results:
- Liver biopsy remains the gold standard for NASH diagnosis.
- Steatosis coupled with an inflammatory response is essential for NASH diagnosis.
- Fibrosis is a significant, albeit variable, feature in NASH.
Conclusions:
- Current treatment for NASH emphasizes weight loss and dietary modifications.
- Adequate vitamin intake is advised.
- Ursodeoxycholic acid is under investigation for NASH treatment.
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