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Updated: Jul 7, 2026
12:23
Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
Published on: April 14, 2014
14.1K
Portable multi-focal visual evoked potential diagnostics for multiple sclerosis/optic neuritis patients
S Mohammad Ali Banijamali1, Craig Versek2, Kristen Babinski3
1Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA.
Documenta Ophthalmologica. Advances in Ophthalmology
|July 2, 2024
Summary
A new portable NeuroVEP system shows promise for diagnosing neuro-visual disorders like multiple sclerosis (MS) and optic neuritis (ON). It accurately assesses visual pathways and fields, aligning with standard methods.
Area of Science:
- Neuroscience
- Ophthalmology
- Medical Devices
Background:
- Multiple sclerosis (MS) is a neuro-inflammatory disease impacting the central nervous system (CNS).
- Optic neuritis (ON), a common MS symptom, involves optic nerve damage and visual pathway disruption.
- Current diagnostic methods for MS-related visual impairment can be time-consuming and lack portability.
Purpose of the Study:
- To develop and evaluate NeuroVEP, a portable, wireless system for diagnosing neuro-visual disorders.
- To assess the system's ability to measure evoked potentials and analyze visual field integrity.
- To compare NeuroVEP performance against standard-of-care (SOC) electrophysiological and visual field tests.
Main Methods:
- NeuroVEP utilizes a smartphone-based headset for visual stimuli and custom scalp electrodes for electroencephalography (EEG).
- A short full-field visual evoked potentials (ffVEP) test assesses overall visual pathway integrity (P100 component).
- A multifocal VEP (mfVEP) test evaluates 36 specific visual field regions, employing signal processing and machine learning for analysis.
Main Results:
- The NeuroVEP system demonstrated high agreement (91%) with SOC ffVEP testing in 20 subjects (10 controls, 10 with MS/ON).
- NeuroVEP mfVEP results showed good correlation with Humphrey Automated Perimetry for visual field analysis.
- Lesion localization derived from mfVEP data was consistent with Magnetic Resonance Imaging (MRI) and Optical Coherence Tomography (OCT) findings.
Conclusions:
- This pilot study suggests NeuroVEP is a potentially reliable and objective tool for electrophysiology and visual field assessment.
- The portable nature of NeuroVEP offers advantages for diagnosing neuro-visual disorders in various clinical settings.
- Further validation is warranted, but NeuroVEP shows promise for improving diagnostic capabilities in MS and ON.
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