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Updated: Jun 22, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

166

Association between admission pan-immune-inflammation value and short-term mortality in septic patients: a

Hong-Bo Xu1, Yu-Hong Xu2, Ying He3

  • 1Department of Critical Care Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital/The 6th Affiliated Hospital of Shenzhen University Health Science Center, 89 Taoyuan Road, Shenzhen, 518052, China.

Scientific Reports
|July 2, 2024
PubMed

Insights

The Pan-Immune-Inflammation Value (PIV) shows a non-linear association with mortality in sepsis patients. Higher PIV levels correlate with increased 28-day and 90-day mortality risks, indicating its prognostic value.

Area of Science:

  • Critical Care Medicine
  • Inflammation Biomarkers
  • Sepsis Pathophysiology

Background:

  • The Pan-Immune-Inflammation Value (PIV) is an emerging inflammation indicator.
  • Sepsis is a life-threatening condition with high mortality rates.
  • Prognostic markers are crucial for managing septic patients.

Purpose of the Study:

  • To investigate the association between PIV and prognosis in septic patients.
  • To determine if PIV can predict mortality in sepsis.
  • To explore the nature of the relationship between PIV and mortality outcomes.

Main Methods:

  • Retrospective analysis of 11,331 septic patients from the MIMIC-IV database.
  • Kaplan-Meier curves to assess survival rates based on PIV.
  • Multivariable Cox regression and restricted cubic spline analyses to evaluate PIV's association with 28-day and 90-day mortality.

Main Results:

  • Higher PIV levels were associated with lower 28-day survival rates.
  • Log2-PIV showed a positive, non-linear association with 28-day mortality risk.
  • An inflection point at log2-PIV=8 indicated increased mortality risk for higher values, with similar trends for 90-day mortality.

Conclusions:

  • PIV demonstrates a significant non-linear relationship with both 28-day and 90-day mortality in septic patients.
  • PIV may serve as a valuable prognostic biomarker in sepsis management.
  • Further research is warranted to elucidate the clinical utility of PIV in sepsis.
Keywords:
InflammationMIMIC-IVMortalityPan-immune-inflammation valueSepsis

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