Related Experiment Video
Updated: Aug 6, 2026
08:47
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
Published on: March 3, 2023
Clinical Heterogeneity in Adult Rhinitis: Symptom-Sensitization Concordance and Asthma Burden
Chong Wang1, Xiu He2, Haigang Zhang2
1Department of Otolaryngology Shenzhen Longgang Otolaryngology Hospital, Shenzhen Otolaryngology Research Institute Shenzhen Guangdong China.
Laryngoscope Investigative Otolaryngology
|July 19, 2026
Summary
Adult rhinitis symptoms and allergen sensitization are linked but distinct. Concordance and discordance reveal specific phenotypes associated with varying asthma and sinonasal issues.
Area of Science:
- Allergy and Immunology
- Respiratory Medicine
- Epidemiology
Background:
- Rhinitis symptoms and allergen sensitization are common in adults.
- Understanding the relationship between rhinitis symptoms and measured sensitization is crucial for identifying distinct patient phenotypes.
- These phenotypes may be associated with different burdens of asthma and sinonasal disease.
Purpose of the Study:
- To classify adults based on the concordance between rhinitis symptoms and measured systemic allergen-specific immunoglobulin E (sIgE) sensitization.
- To investigate the patterns of associated asthma and sinonasal burden within these classified groups.
Main Methods:
- Analysis of data from US adults (aged 20+) in the NHANES 2005-2006 survey.
- Rhinitis symptoms defined as hay fever or nasal symptoms in the past 12 months.
- Systemic sensitization defined by serum sIgE levels to 19 allergens (≥0.35 kU/L).
- Survey-weighted logistic regression used to estimate associations.
Main Results:
- Among 4220 adults, phenotypes included concordant negative (38.7%), isolated sensitization (24.6%), isolated rhinitis symptoms (17.7%), and concordant positive (19.0%).
- Concordant positive rhinitis and sensitization showed the highest odds of asthma (OR, 6.21).
- Isolated rhinitis symptoms were linked to increased odds of sinus infection (OR, 3.16) and sleep impairment.
Conclusions:
- Rhinitis symptoms and measured systemic sensitization are related but not interchangeable.
- Concordance and discordance between symptoms and sensitization define distinct adult rhinitis phenotypes.
- These phenotypes are associated with specific patterns of asthma and sinonasal disease burden.
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