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Updated: Jun 8, 2026
A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
Prevalence of Self-reported COVID-19 Infection in Persons With Complicated Mild to Severe Traumatic Brain Injury: A
Shanti M Pinto1, Leah M Adams, Audrie Chavez
1From the Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, Texas (SMP); Department of Psychology and Women & Gender Studies program, George Mason University, Fairfax, Virginia (LMA); Department of Rehabilitation Medicine, University of Texas Health Science Center, San Antonio, Texas (AC); School of Data Science and Department of Psychology, University of Virginia, Charlottesville, Virginia (PBP); Central Virginia Veterans Affairs Health Care System, Richmond, Virginia (PBP); Drucker Brain Injury Center, Jefferson Moss-Magee Rehabilitation, Elkins Park, Pennsylvania (TKW); Neurorehabilitation Laboratory, Spaulding Rehabilitation Hospital, Boston, Massachusetts (KG); Department of Rehabilitation Science, MGH Institute of Health Professions, Boston, Massachusetts (KG); Department of Rehabilitative Services, Brigham and Women's Hospital, Boston, Massachusetts (KG); Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts (AS); Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington (JMH); Department of PM&R, Harvard Medical School, Boston, Massachusetts (DHD); Moss Rehabilitation Research Institute, Thomas Jefferson University, Philadelphia, Pennsylvania (ARR); Baylor Scott & White Research Institute, Dallas, Texas (LC); Department of Physical Medicine & Rehabilitation, Indiana University School of Medicine, Indianapolis, Indiana (FMH); and Rehabilitation Hospital of Indiana, Indianapolis, Indiana (FMH).
Objectives:
The aims of the study are to describe the incidence of self-reported COVID-19 history in a longitudinal cohort of individuals with complicated mild to severe traumatic brain injury and describe demographic, injury, and functional differences based on history of COVID-19 infection.
Design:
Individuals with complicated mild to severe traumatic brain injury aged 16 or older at time of injury who were enrolled in the Traumatic Brain Injury Model Systems longitudinal cohort study, completed a baseline or follow-up interview between October 1, 2021-March 31, 2023, and provided information about COVID-19 history and timing of COVID-19 infection was collected.
Results:
Of the 3627 individuals included in the analysis, 29.5% reported a history of COVID-19 infection. Those with reported COVID-19 history tended to be younger, not of a racial/ethnic minority background, and greater functional status at follow-up based on the Glasgow Outcome Scale-Extended Scale compared with those with no reported COVID-19 history ( P < 0.05). Among those with COVID-19 history, 61.8% did not receive medical care, 27.6% received medical care but no hospitalization, and 10.5% were hospitalized. Of those hospitalized, 21.4% required ventilator use.
Conclusions:
Incidence of COVID-19 diagnosis and related hospitalization characteristics in persons with complicated mild to severe traumatic brain injury was similar to national incidence between March 2020-2023. Secondary effects of the COVID-19 pandemic on persons with traumatic brain injury require investigation.
