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Complicated urinary tract infections.

L C Preheim

    The American Journal of Medicine
    |August 9, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Complicated urinary tract infections (UTIs) often occur in older men and are linked to urinary abnormalities. Effective treatment requires addressing underlying causes and managing antimicrobial resistance, especially in hospital-acquired cases.

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    Area of Science:

    • Urology
    • Infectious Diseases
    • Microbiology

    Background:

    • Urinary tract infections (UTIs) are categorized as complicated or uncomplicated based on urinary tract abnormalities.
    • Complicated UTIs present distinct patient profiles, settings, pathogens, antimicrobial susceptibility patterns, and treatment strategies compared to uncomplicated UTIs.

    Purpose of the Study:

    • To delineate the key differences between complicated and uncomplicated urinary tract infections.
    • To highlight the specific challenges and considerations in managing complicated UTIs, particularly in hospital-acquired settings.

    Main Methods:

    • Comparative analysis of patient demographics, predisposing factors, and clinical characteristics.
    • Review of common pathogens, antimicrobial susceptibility profiles, and treatment outcomes.

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  • Examination of the impact of hospital-acquired infections and indwelling urinary catheters.

    • Main Results:

    • Complicated UTIs are prevalent in older males with prostatic enlargement, frequently caused by Gram-negative bacilli.
    • Isolates from complicated UTIs exhibit higher resistance to older antibiotics, necessitating parenteral therapy.
    • Hospital-acquired UTIs, often associated with catheters, demonstrate significant antimicrobial resistance, contributing to morbidity, mortality, and healthcare costs.

    Conclusions:

    • While numerous treatments exist for uncomplicated UTIs, complicated infections require tailored antimicrobial choices based on patient factors and causative organisms.
    • Resolving the predisposing condition is crucial for successful treatment of complicated urinary tract infections, even with novel antibiotics.