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Why do some individuals with obesity remain metabolically healthy?
Christoph Buettner1, Kenichi Sakamoto1, Mary A Butera1
1Division of Endocrinology, Metabolism & Nutrition, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Trends in Endocrinology and Metabolism: TEM
|July 3, 2024
Summary
Metabolically unhealthy obesity (MUO) drives significant cardiometabolic disease and mortality. Understanding MUO pathogenesis is crucial for addressing the obesity epidemic and its health consequences.
Area of Science:
- Obesity and metabolic health research
Background:
- Obesity is a major public health concern linked to increased cardiometabolic disease and mortality.
- Distinguishing between metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) is critical for understanding health risks.
Purpose of the Study:
- To provide in-depth characterization of individuals with MHO and MUO.
- To gain insights into the potential pathogenesis of MUO.
Main Methods:
- The study characterized individuals with MHO and MUO in depth.
Main Results:
- The characterization provided insights into the potential pathogenesis of MUO.
Conclusions:
- MUO accounts for a significant portion of the cardiometabolic disease and excess mortality associated with the obesity epidemic.
- Further research into MUO pathogenesis is warranted to mitigate its impact.
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