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Updated: Jun 13, 2026
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
Published on: August 4, 2018
Analysis of the Antimicrobial Activity of Epigallocatechin-3-Gallate (EGCG)
V V Muravieva1, B O Bembeeva2, T V Priputnevich1
1National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V. I. Kulakov of Ministry of Health of Russian Federation, Moscow, Russia.
Abstract:
We studied antimicrobial activity of epigallocatechin-3-gallate (EGCG), a green tea polyphenolic catechin, and its combined use with ceftazidime (CAZ) against bacterial strains of Klebsiella pneumoniae. EGCG exhibited no activity against strains of K. pneumoniae with a different sensitivity to CAZ. However, for a "sensitive" strain, a decrease in minimum inhibitory concentration (MIC) of CAZ (from 0.064 to 0.023 mg/liter) was revealed when CAZ was co-administered with EGCG. For a "resistant" stain, MIC of CAZ remained high, but activation of EGCG at its high concentrations was observed. Indirect evidence of antimicrobial effect of EGCG co-administered with CAZ on Klebsiella was obtained.
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