Related Experiment Video
Updated: Jun 22, 2025
14:56
The Combined Use of Transcranial Direct Current Stimulation and Robotic Therapy for the Upper Limb
Published on: September 23, 2018
9.0K
Universal CAR 2.0 to overcome current limitations in CAR therapy
Lara Sophie Schlegel1, Coralie Werbrouck1, Michael Boettcher2
1School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Frontiers in Immunology
|July 4, 2024
Summary
Chimeric antigen receptor (CAR) T cell therapy shows promise for hematological cancers. Advanced CAR technologies aim to expand treatments beyond current limitations, addressing manufacturing bottlenecks and enabling personalized medicine.
Area of Science:
- Immunology
- Oncology
- Biotechnology
Background:
- Chimeric antigen receptor (CAR) T cell therapy is effective for advanced hematological cancers.
- CD19- and BCMA-CAR T therapies have achieved significant success, raising expectations for broader applications.
Purpose of the Study:
- To review the fundamental prerequisites, challenges, and strategies for extending CAR T cell therapy beyond current indications.
- To explore advanced CAR technologies for overcoming limitations of conventional CAR concepts.
Main Methods:
- Comprehensive review of existing literature and emerging CAR technologies.
- Analysis of innovations in combinatorial targeting and adapter CAR concepts.
- Discussion of next-generation CAR designs for multitargeted immunotherapies.
Main Results:
- Advanced CAR technologies, including combinatorial targeting and adapter CARs, offer solutions to antigen heterogeneity.
- These innovations promise to overcome CAR manufacturing bottlenecks.
- Patient-individualized treatment regimens are becoming more feasible with next-generation CAR designs.
Conclusions:
- The development of multitargeted immunotherapies using universal CAR technologies is a key future direction.
- Overcoming current limitations will pave the way for broader CAR T cell therapy applications.
- Strategic approaches are crucial for establishing the future of universal CAR technologies in cancer treatment.
Related Concept Videos
01:27Otto and Diesel Cycle
1.6K
An Otto engine is a four-stroke engine that uses a mixture of gasoline and air as the working fuel. The fuel is injected into the cylinder, and the piston is moved completely down so that the cylinder is at maximum volume. By moving the piston up, adiabatic compression takes place. The spark plug ignites the gasoline-air mixture, and the burning fuel adds heat to the system at a constant volume. The heated mixture expands adiabatically and gets further cooled by exhausting heat, and this cyclic...
1.6K
01:26Modeling in Therapy
65
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
65
01:20Internal Combustion Engine
1.1K
The internal combustion engine is a heat engine that uses the byproducts of combustion as the working fluid instead of using a heat transfer medium to transfer heat. The combustion is done in a way that produces high-pressure combustion products that can be expanded through a turbine or piston to create work. Internal combustion engines can again be categorized into three kinds: (1) spark ignition gasoline engines, most commonly used in automobiles, (2) compression ignition diesel engines that...
1.1K
01:17Rolling Resistance: Problem Solving
319
Rolling resistance, also known as rolling friction, is the force that resists the motion of a rolling object, such as a wheel, tire, or ball, when it moves over a surface. It is caused by the deformation of the object and the surface in contact with each other, as well as other factors like internal friction, hysteresis, and energy losses within the materials. Rolling resistance opposes the object's motion, requiring additional energy to overcome it and maintain movement. In practical...
319
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:24Parkinson's Disease: Treatment
251
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
251