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Updated: Jun 22, 2025

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
Ru(0)-catalysed synthesis of borylated polyene building blocks by cross-dimerisation toward cross-coupling
Masafumi Hirano1, Sayori Kiyota1
1Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakacho, Koganei, Tokyo 184-8588, Japan. hrc@cc.tuat.ac.jp.
Abstract:
Conjugated and non-conjugated polyenes are important substructures and are often found in biologically active compounds and natural products. Their preparation often needs multiple steps or iterative reactions and as a result, they have poor step economies. In this feature article, we show a new methodology to prepare these substructures by combinations of cross-dimerisation giving borylated polyenes and subsequent cross-coupling reactions. This divergent reaction strategy allows for the opportunity to access many bioactive compounds and natural products as well as some electronic materials.
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