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Related Experiment Videos

Free intraglomerular malarial antigens.

M Pakasa, B Van Damme, V J Desmet

    British Journal of Experimental Pathology
    |August 1, 1985
    PubMed
    Summary
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    Nude mice infected with Plasmodium berghei show malarial antigens in their glomeruli, even without antibody production. This suggests free malarial antigens deposit in the kidney, potentially forming immune complexes in other mice.

    Area of Science:

    • Immunology
    • Parasitology
    • Nephrology

    Background:

    • Plasmodium berghei infection causes lethal disease in mice.
    • Nude athymic mice lack circulating antibodies (IgG, IgM) but can be used to study antigen deposition.

    Purpose of the Study:

    • To investigate the localization of Plasmodium berghei antigens in the kidneys of nude mice.
    • To determine if kidney antigen deposition is related to antibody production or other immunoreactants.

    Main Methods:

    • Infection of nude athymic mice with Plasmodium berghei.
    • Detection of plasmodium-related antigens in glomeruli via immunofluorescence.
    • Assessment of other immunoreactants (IgG, IgM, C3) and auto-antibodies.

    Main Results:

    Related Experiment Videos

    • Plasmodium-related antigens were detected in the glomeruli of infected nude mice.
    • Antigen deposition correlated with rising parasitemia and was independent of IgG, IgM, or C3 deposition.
    • No correlation was found between auto-antibodies or other immunoreactants and the infection course.

    Conclusions:

    • Free malarial antigens can localize within the glomeruli of mice lacking antibody production.
    • This intraglomerular antigen deposition may be a precursor to in situ immune complex formation in immunocompetent hosts.