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Inflammatory eye disease is a risk factor for future microscopic colitis: A nationwide population-based matched case
David Bergman1, Fahim Ebrahimi1,2, Jiangwei Sun1
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
United European Gastroenterology Journal
|July 4, 2024
Summary
Inflammatory eye diseases, such as iridocyclitis and episcleritis, are more common in individuals who later develop microscopic colitis (MC). This suggests shared causes and inflammatory pathways between these conditions.
Area of Science:
- Gastroenterology
- Ophthalmology
- Epidemiology
Background:
- Microscopic colitis (MC) is a colonic inflammatory disorder.
- The link between inflammatory eye diseases and MC is not well understood.
Purpose of the Study:
- To determine if inflammatory eye disease is a risk factor for developing MC.
Main Methods:
- A nationwide matched case-control study in Sweden (ESPRESSO-study) was conducted.
- 14,338 patients with biopsy-verified MC were matched with 68,753 controls.
- Preceding inflammatory eye diseases (episcleritis or iridocyclitis) were compared between groups.
Main Results:
- 1.6% of MC patients had a history of inflammatory eye disease, versus 0.9% in controls.
- This corresponded to an adjusted odds ratio (aOR) of 1.77 for inflammatory eye diseases in MC patients.
- Previous inflammatory eye diseases were also more common in MC patients compared to their siblings.
Conclusions:
- Inflammatory eye diseases are more prevalent in individuals who are later diagnosed with MC.
- Shared underlying causes and inflammatory pathways may link these conditions.
- Findings are relevant for gastroenterologists, ophthalmologists, and general practitioners.
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