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Updated: Jun 22, 2025
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Multifaceted Interventions Inclusive of Medication Optimization for Frailty in Aged Care: A Systematic Review
Chidiamara M Njoku1, Fiona Barnett1, Maria A Fiatarone Singh2
1College of Healthcare Sciences, Sport and Exercise Science, James Cook University, Townsville, Queensland, Australia.
Summary
Research on combined medication, exercise, and nutrition for frailty in aged care is lacking. This review found no studies meeting these criteria, highlighting a critical gap in evidence for this vulnerable population.
Area of Science:
- Gerontology
- Pharmacology
- Geriatric Medicine
Background:
- Frailty is a significant concern in residential aged care, impacting health outcomes.
- Polypharmacy is common in older adults and is closely linked to frailty.
- Evidence for multifaceted frailty interventions, including medication optimization, in aged care is scarce.
Purpose of the Study:
- To systematically review literature on medication optimization combined with exercise and/or nutrition for frailty management in residential aged care.
- To evaluate the effectiveness of these combined interventions in improving frailty status.
Main Methods:
- Systematic review with qualitative synthesis.
- Searched five electronic databases from inception to November 2023.
- Included 3 studies (2 RCTs, 1 non-RCT) involving 1030 participants.
Main Results:
- No studies combined medication review, exercise, and nutrition for frailty in aged care.
- Medication review alone reduced the number of prescribed medications.
- Nutritional support reduced gastrointestinal medication use and maintained participant weight.
Conclusions:
- There is a lack of research on best-practice guidelines for combined medication optimization, exercise, and nutrition in aged care to address frailty.
- Further studies are urgently needed to implement consensus guidelines for frailty treatment in this population.
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