Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of RNA01:23

Types of RNA

63.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
63.5K
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
RNA Stability01:53

RNA Stability

33.5K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
33.5K
RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

9.2K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "miRNA-206 in muscle and central nervous system crosstalk during exercise: A double-edged sword with therapeutic potential" [Neurosci. Biobehav. Rev. 183 (2026) 106569].

Neuroscience and biobehavioral reviews·2026
Same author

Serum BDNF as an integrative neuro-immunometabolic marker in adolescent polycystic ovary syndrome: divergent dietary and inflammatory associations across weight phenotypes.

Frontiers in nutrition·2026
Same author

Comparative Effectiveness and Safety of Tofacitinib, Filgotinib, and Upadacitinib in Ulcerative Colitis: A Multicenter Real-World Cohort Study.

Advances in therapy·2026
Same author

Dynamics of slow wave sleep in advanced Parkinson's disease: An entropy-based study.

Neurobiology of disease·2026
Same author

Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia.

Leukemia·2026
Same author

Altered wakeful theta activity characterizes levodopa-induced dyskinesia in Parkinson's disease.

NPJ Parkinson's disease·2026

Related Experiment Video

Updated: Jun 22, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.6K

RNA-binding proteins in bone pathophysiology.

Paola Maroni1, Noemi Anna Pesce1, Giovanni Lombardi1,2

  • 1Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Milano, Italy.

Frontiers in Cell and Developmental Biology
|July 5, 2024
PubMed
Summary

RNA Binding Proteins (RBPs) regulate bone cell activity, balancing bone formation and resorption. Understanding RBPs offers insights into bone health and disease, crucial for maintaining skeletal integrity and mineral homeostasis.

Keywords:
RNA binding proteins (RBPs)bone agingbone cancerbone metastasisbone pathophysiologymodulation of mRNAsosteoporosispost-transcriptional regulatory mechanisms

More Related Videos

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.6K
Novel RNA-Binding Proteins Isolation by the RaPID Methodology
11:19

Novel RNA-Binding Proteins Isolation by the RaPID Methodology

Published on: September 30, 2016

9.0K

Related Experiment Videos

Last Updated: Jun 22, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.6K
Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.6K
Novel RNA-Binding Proteins Isolation by the RaPID Methodology
11:19

Novel RNA-Binding Proteins Isolation by the RaPID Methodology

Published on: September 30, 2016

9.0K

Area of Science:

  • Biochemistry
  • Cell Biology
  • Skeletal Biology

Background:

  • Bone remodeling is a vital physiological process for skeletal integrity and mineral homeostasis.
  • This process involves complex intercellular communication between osteoblasts and osteoclasts.
  • Dysregulation of bone remodeling contributes to various bone pathologies.

Purpose of the Study:

  • To review the physiological and pathological roles of RNA Binding Proteins (RBPs) in bone.
  • To elucidate the molecular mechanisms by which RBPs regulate bone cell function.
  • To highlight the potential of RBPs as therapeutic targets for bone diseases.

Main Methods:

  • Literature review of recent studies on RBPs in bone biology.
  • Analysis of the molecular functions of RBPs in gene expression regulation.
  • Examination of the impact of RBPs on osteoblast and osteoclast activity.

Main Results:

  • RBPs are key regulators of gene expression, influencing cell fate decisions in bone cells.
  • Specific RBPs have been identified to play critical roles in balancing bone formation and resorption.
  • Alterations in RBP function are implicated in the pathophysiology of bone disorders.

Conclusions:

  • RBPs are essential regulators of bone remodeling and cellular communication within bone tissue.
  • Targeting RBPs may offer novel therapeutic strategies for treating bone diseases.
  • Further research into RBP mechanisms will advance our understanding of bone health and disease.