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Mini-review: research and progress of oxeiptosis in diseases

Ke-Qian Chen1, Shu-Zhi Wang2, Hai-Bo Lei1

  • 1Department of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, China.

Frontiers in Cell and Developmental Biology
|July 5, 2024
PubMed

Insights

Oxeiptosis, a novel cell death pathway, is induced by reactive oxygen species (ROS) and distinct from other regulated cell death forms. Understanding its mechanisms is key for targeting diseases.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Pathology

Background:

  • Oxeiptosis is a recently identified regulated cell death pathway initiated in 2018.
  • It is induced by reactive oxygen species (ROS) and operates independently of caspases.
  • Oxeiptosis is differentiated from apoptosis, necroptosis, pyroptosis, and ferroptosis by unique causative factors, genes, and signaling pathways (KEAP1/PGAM5/AIFM1).

Purpose of the Study:

  • To systematically review the latest advancements in oxeiptosis-related diseases.
  • To elucidate the molecular mechanisms and regulatory networks governing oxeiptosis.
  • To provide a foundation for understanding oxeiptosis's role in disease and potential therapeutic targeting.

Main Methods:

  • Systematic literature review of oxeiptosis research.
  • Analysis of molecular mechanisms and signaling pathways (KEAP1/PGAM5/AIFM1).
  • Examination of oxeiptosis's involvement in various disease pathologies.

Main Results:

  • Oxeiptosis involves unique damage triggers, pivotal genes, and the KEAP1/PGAM5/AIFM1 signaling axis.
  • Emerging evidence links oxeiptosis to the progression of diverse diseases.
  • Dysregulation of oxeiptosis presents potential therapeutic targets.

Conclusions:

  • Oxeiptosis is a distinct regulated cell death pathway with significant implications in disease.
  • Further research into its molecular intricacies is crucial for therapeutic development.
  • Understanding oxeiptosis offers new avenues for disease intervention.
Keywords:
AIFM1KEAP1PGAM5ROSoxeiptosis

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