Related Experiment Video
Updated: Jul 6, 2026
Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
Effect of Elevated Neutrophil-to-Lymphocyte Ratio on Adverse Outcomes in Patients With Myocardial Infarction: A
Nana O Banahene1, Tanya Sinha2, Sanam Shaikh3
1Internal Medicine, Nanjing Medical University, Nanjing, CHN.
Insights
Elevated neutrophil-to-lymphocyte ratio (NLR) significantly increases the risk of major adverse cardiovascular events (MACE) and all-cause mortality in myocardial infarction (MI) patients. This finding highlights NLR as a crucial prognostic marker for MI outcomes.
Area of Science:
- Cardiovascular Medicine
- Inflammation Biomarkers
- Clinical Prognostics
Background:
- Myocardial infarction (MI) is a major global health concern, driven by inflammatory processes like atherosclerosis.
- Systemic inflammation markers, such as the neutrophil-to-lymphocyte ratio (NLR), are increasingly recognized for their prognostic potential in cardiovascular diseases.
Purpose of the Study:
- To evaluate the association between elevated NLR and the risk of major adverse cardiovascular events (MACE) and all-cause mortality in patients with MI.
- To synthesize evidence from existing studies to provide a comprehensive assessment of NLR's predictive value in MI.
Main Methods:
- A systematic literature search was conducted across Embase, Web of Science, PubMed, and OVID Medicine for studies published from January 1, 2011, onward.
- Included studies focused on adult MI patients (STEMI and NSTEMI), analyzing the impact of NLR on MACE and mortality.
- Data extraction and quality assessment were performed independently; a meta-analysis pooled the results from 37 studies (18 for MACE, 30 for mortality).
Main Results:
- Elevated NLR was significantly associated with an increased risk of MACE (OR 1.86, 95% CI 1.53-2.28, P < 0.01).
- A significantly higher risk of all-cause mortality was observed in patients with elevated NLR (OR 2.29, 95% CI 1.94-2.70, P < 0.01).
- Subgroup analyses confirmed the consistent association between elevated NLR and adverse outcomes, irrespective of follow-up duration or study design.
Conclusions:
- This meta-analysis confirms a significant link between elevated NLR and increased risks of MACE and all-cause mortality in MI patients.
- NLR demonstrates potential as a valuable prognostic marker for risk stratification in myocardial infarction.
- Further research is warranted to validate NLR's predictive capabilities and establish optimal cutoff values for clinical application.
Abstract:
Myocardial infarction (MI), a leading cause of morbidity and mortality globally, is characterized by an underlying inflammatory process driven by atherosclerosis. The neutrophil-to-lymphocyte ratio (NLR), a readily available and cost-effective marker of systemic inflammation, has emerged as a potential predictor of adverse outcomes in patients with MI. This meta-analysis aimed to evaluate the association between elevated NLR and the risk of major adverse cardiovascular events (MACE) and all-cause mortality in patients with MI. A comprehensive literature search was conducted across multiple databases, including Embase, Web of Science, PubMed, and OVID Medicine, to identify relevant studies published from January 1, 2011, onward. Studies reporting the effect of NLR values on MACE and mortality in adult patients with MI, including both ST-elevation (STEMI) and non-ST-elevation (NSTEMI) subtypes, were included. Data extraction and quality assessment were performed independently by multiple authors. The meta-analysis included 37 studies, comprising a total of 18 studies evaluating the risk of MACE and 30 studies assessing all-cause mortality. The pooled analysis revealed a significantly increased risk of MACE (odds ratio [OR] 1.86, 95% confidence interval [CI] 1.53-2.28, P < 0.01) and all-cause mortality (OR 2.29, 95% CI 1.94-2.70, P < 0.01) in patients with elevated NLR compared to those without elevated NLR. Subgroup analyses stratified by follow-up duration and study design further supported the consistent association between elevated NLR and adverse outcomes. In conclusion, this meta-analysis demonstrates a significant association between elevated NLR and an increased risk of MACE and all-cause mortality in patients with MI. These findings highlight the potential clinical utility of NLR as a prognostic marker and underscore the importance of further research to validate its predictive value and establish optimal cutoff values for risk stratification in this patient population.
Related Concept Videos
01:22Myocarditis IV: Nursing Management
01:30Acute Coronary Syndrome III: Diagnostic Studies