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Selective Tumor Inhibition Effect of Drug-Free Layered Double Hydroxide-Based Films via Responding to Acidic

Shun Xing1,2, Haifeng Zhang1,2, Lidan Liu1,2

  • 1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.

ACS Biomaterials Science & Engineering
|July 5, 2024
PubMed

Insights

Researchers developed an acid-responsive film for nickel-titanium alloy stents. This film selectively targets cancer cells and bacteria in the tumor microenvironment, enhancing treatment efficacy and safety.

Area of Science:

  • Biomaterials Science
  • Oncology
  • Nanotechnology

Background:

  • Nickel-titanium alloy stents are crucial for treating malignant tumors but face challenges from tumor invasion and bacterial colonization.
  • Developing functionalized stents with targeted anticancer and antibacterial properties is essential for improving patient outcomes.
  • Current strategies require enhancement to prevent complications like malignant obstruction.

Purpose of the Study:

  • To engineer an acid-responsive layered double hydroxide (LDH) film on nickel-titanium alloy stents.
  • To investigate the film's selective cancer-inhibiting and antibacterial capabilities.
  • To optimize the stent's therapeutic potential for tumor treatment.

Main Methods:

  • Hydrothermal treatment was used to construct an acid-responsive LDH film on nickel-titanium alloy surfaces.
  • The release of nickel ions from the LDH film in acidic conditions was analyzed.
  • Heat treatment was employed to tune the LDH nanosheet surface area and nickel ion release rate.
  • Antibacterial activity against *S. aureus* and *E. coli* was evaluated.
  • Cytotoxicity assays were performed on normal cells.

Main Results:

  • The acid-responsive LDH film effectively induced oxidative stress and cell death in cancer cells within the acidic tumor microenvironment.
  • Heat treatment allowed modulation of nickel ion release, enhancing the antitumor effect.
  • The LDH film demonstrated significant antibacterial activity against *S. aureus* and *E. coli*.
  • The developed film exhibited low toxicity to normal cells in physiological conditions.

Conclusions:

  • The acid-responsive LDH film offers a promising strategy for developing functional nickel-titanium alloy stents.
  • This approach provides selective cancer inhibition and antibacterial action, minimizing harm to healthy tissues.
  • The study guides the design of advanced stents for improved interventional tumor treatment.
Keywords:
antibacterialantitumorlayered double hydroxidenickel−titanium alloy

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