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Updated: Jun 21, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
"Naked Nickel"-Catalyzed Amination of Heteroaryl Bromides
Rakan Saeb1, Bryan Boulenger1, Josep Cornella1
1Max-Planck-Institut für Kohlenforschung, Department of Organometallic Chemistry, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, North Rhine-Westphalia, Germany.
Abstract:
In this Letter, we report that the air-stable "naked nickel" [Ni(4-stb)3] is a competent catalyst in thermal C-N bond formation between (hetero)aryl bromides and N-based nucleophiles. The catalytic system is characterized by a "naked nickel" complex and Zn and by the absence of external light sources, photocatalysts, exogenous ligands, and electrical setups. Upon application of this method, various heteroaryls bearing Lewis-basic heteroatoms can be accommodated and directly aminated with a set of primary and secondary amines.
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