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Updated: Jun 21, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Oral Mucosa and Saliva Alterations Related to Vape
Bruna Fernandes do Carmo Carvalho1, Natália de Carvalho Faria1, Letícia Foiani2
1Universidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia e of Science and Technology, Câmpus São José dos Campos, São Paulo, Brazil.
Objectives:
Electronic nicotine delivery systems (e-cigarette, pod, and vape) are currently among the tobacco consumption of adolescents and young adults. The aim is to show oral mucosa and saliva alterations related to vape.
Material And Methods:
A vape-user patient, presenting a white plaque in the posterior region of the hard palate, underwent clinical examination, sialometry, pH evaluation, and excisional biopsy of the white lesion. Molecular changes in saliva and vape liquid were analyzed by vibrational spectroscopy.
Results:
The histopathological analyses showed hyperparakeratosis without dysplasia. Formaldehyde, ketones, and aromatic hydrocarbon species were identified in e-cig liquid by the FTIR.
Conclusions:
The use of vape may be related to the development of hyperkeratotic lesions in the oral mucosa as well as significantly modify the patient's salivary patterns as the vape liquid presents carcinogenic and cytotoxic components in its composition.
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