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The value of contrast-enhanced ultrasound in differentiating benign from malignant retroperitoneal masses
Ehsan Safai Zadeh1, Christian Görg2, Helmut Prosch3
1Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria; Interdisciplinary Centre of Ultrasound Diagnostics, Philipps University Marburg, Baldingerstraße Marburg, Germany.
Objectives:
To evaluate the value of contrast-enhanced ultrasound (CEUS) perfusion patterns in the differentiation of benign and malignant retroperitoneal masses (RMs).
Methods:
Between 2006 and 2023, 122 consecutive patients with an RM visualizable by B-mode US were investigated additionally with CEUS. On CEUS, the extent of enhancement (classified as marked, reduced, or absent) and the homogeneity of enhancement (HE; classified as homogeneous or inhomogeneous) were evaluated. Subsequently, the malignancy rate according to CEUS perfusion patterns was determined.
Results:
On CEUS, marked enhancement was significantly more frequently associated with malignancy than with benignity (p < 0.0001, Fisher's exact test). All lesions with no enhancement were benign. Regarding HE, there was no significant difference between benign and malignant lesions (p = 0.07, Fisher's exact test).
Conclusion:
On CEUS, marked enhancement in an RM may be indicative of a malignant lesion. Furthermore, absent enhancement can be considered to be an indication of benignity. The use of CEUS can be helpful in the evaluation of the malignancy of retroperitoneal masses.
