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Updated: Jun 21, 2025
09:34
Pneumococcus Infection of Primary Human Endothelial Cells in Constant Flow
Published on: October 31, 2019
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Pneumococcal infective endocarditis in Brazil: a multicenter study on a severe condition
Roxana Flores Mamani1, Rinaldo Focaccia Siciliano2, Claudio Querido Fortes3
1Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brazil.
Summary
Pneumococcal infective endocarditis (IE) is rare but aggressive, causing high mortality. Prompt diagnosis and surgical intervention are crucial for survival, and vaccination is recommended for at-risk individuals.
Area of Science:
- Infectious Diseases
- Cardiology
- Critical Care Medicine
Background:
- Streptococcus pneumoniae bacteremia can lead to Infective Endocarditis (IE).
- Historically, pneumococcal IE accounted for 10-15% of IE cases pre-antibiotics, now less than 3%.
- Despite rarity, pneumococcal IE presents as an aggressive disease.
Purpose of the Study:
- To analyze the characteristics and outcomes of pneumococcal infective endocarditis.
- To highlight the clinical presentation, management, and mortality associated with pneumococcal IE.
Main Methods:
- Retrospective analysis of endocarditis databases.
- Prospective data collection across 4 Brazilian institutions from 2005 to 2023.
- Inclusion of 2321 adult patients with IE, identifying 11 with pneumococcal IE.
Main Results:
- Eleven cases (0.47%) of pneumococcal IE were identified among 2321 patients.
- Native valve involvement was universal, with perivalvular abscess in 6/11 patients.
- In-hospital mortality was high (6/11), significantly lower in surgically treated patients (1/6) versus those with surgical indication but not operated on (5/5).
Conclusions:
- Pneumococcal endocarditis requires prompt identification and management due to high mortality.
- Surgical intervention is often indicated and associated with improved survival.
- Physician recommendation of vaccination for at-risk patients is crucial to prevent severe pneumococcal disease.
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