Related Experiment Video
Updated: Jun 21, 2025
03:40
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
438
First-Generation OTC Antihistamine Use and Voice Function in Individuals with Allergic Rhinitis: A Preliminary Report
Rebecca J Hall-Landers1, Mariah E Morton-Jones2, Laura W Plexico1
1Department of Speech, Language, & Hearing Sciences, Auburn University, Auburn, Alabama.
Summary
Routine over-the-counter antihistamine use in allergic rhinitis patients showed no voice function changes but did reveal laryngeal mucosal changes, suggesting potential vocal fold adaptations.
Area of Science:
- Otolaryngology
- Allergology
- Speech-Language Pathology
Background:
- Allergic rhinitis commonly affects individuals, often managed with over-the-counter antihistamines.
- Laryngeal effects of routine antihistamine use in this population are not well-documented.
Purpose of the Study:
- To investigate the impact of Chlor-Trimeton on laryngeal structure and function.
- To study individuals with allergic rhinitis who routinely use antihistamines but report no voice disorders.
Main Methods:
- Prospective, within-participant, repeated measures design.
- Eight participants with allergic rhinitis and no voice disorder history completed measures before and after antihistamine intake.
- Measures included perceptual voice, phonation threshold pressure (PTP), acoustic analysis, and laryngeal imaging.
Main Results:
- No significant changes in acoustic or aerodynamic measures were observed.
- Laryngeal imaging revealed mucosal changes (increased vascularity, mucus, vocal fold color changes) consistent with 'allergy larynx'.
- Phonation threshold pressure remained stable.
Conclusions:
- Clinical observations of laryngeal tissue changes in allergic rhinitis are affirmed.
- Stable PTP suggests possible vocal fold cover adaptations to routine antihistamine use, potentially mitigating drying effects.
Related Concept Videos
01:15Upper Respiratory Drugs: First and Second-Generation Antihistamines
240
Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
240
01:16Drugs Used in Upper Respiratory Disorders: Overview
209
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
209
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
267
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
267
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
267
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
267
01:28Adrenergic Agonists: Mixed-Action Agents
700
Mixed-action adrenergic agonists, like ephedrine and pseudoephedrine, directly and indirectly affect adrenergic receptors. These agents stimulate adrenoceptors and indirectly release stored neurotransmitters, amplifying the adrenergic response.
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
700
01:27Upper Respiratory Drugs: Decongestants
201
Decongestants are a class of medications used primarily to alleviate nasal congestion, a common symptom resulting from allergies, colds, sinusitis, and other upper respiratory tract infections. These drugs work by activating α-adrenergic receptors, constricting small blood vessels in the nasal membranes. This action results in the opening of clogged nasal passages, thereby facilitating sinus drainage and relieving congestion.
Most decongestants are readily available over-the-counter in...
Most decongestants are readily available over-the-counter in...
201