Related Experiment Video
Updated: Jun 26, 2026
09:05
Minimal Invasive Surgical Procedure of Inducing Myocardial Infarction in Mice
Published on: May 4, 2015
27.7K
Culprit-Only Revascularization, Single-Setting Complete Revascularization, and Staged Complete Revascularization in
Muhammad Haisum Maqsood1, Jacqueline E Tamis-Holland2, Sunil V Rao3
1Department of Cardiology, DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (M.H.M.).
Circulation. Cardiovascular Interventions
|July 8, 2024
Summary
Single-setting complete revascularization offers the best outcomes for acute myocardial infarction (MI) patients with multivessel disease. This approach reduces cardiovascular events more effectively than staged complete or culprit-only revascularization.
Area of Science:
- Cardiology
- Interventional Cardiology
- Clinical Trials
Background:
- Complete revascularization improves outcomes in acute myocardial infarction (MI) with multivessel coronary artery disease.
- The optimal timing for complete revascularization (single-setting vs. staged) remains uncertain.
Purpose of the Study:
- To compare the cardiovascular outcomes of single-setting complete, staged complete, and culprit vessel-only revascularization in acute MI patients with multivessel disease.
Main Methods:
- A systematic review and meta-analysis of 16 randomized controlled trials involving 11,876 patients.
- Databases searched included PubMed, EMBASE, and clinicaltrials.gov.
Main Results:
- Both single-setting and staged complete revascularization significantly reduced major adverse cardiovascular events, MI, and repeat revascularization compared to culprit-only treatment.
- Single-setting complete revascularization demonstrated superior outcomes over staged complete revascularization for cardiovascular mortality/MI and major adverse cardiovascular events.
- Single-setting complete revascularization was ranked as the optimal strategy, followed by staged complete, then culprit-only revascularization.
Conclusions:
- Single-setting complete revascularization may provide the greatest reduction in cardiovascular events for acute MI patients with multivessel disease.
- Further large-scale randomized trials are needed to definitively establish the optimal timing for complete revascularization.
Keywords:
ST elevation myocardial infarctionmeta-analysismyocardial infarctionpercutaneous coronary interventionMore Related Videos
Related Concept Videos
01:27Coronary Artery Disease V: Interprofessional Care
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
01:30Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:28Acute Coronary Syndrome IV: Interprofessional Care
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...